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OBJECTIVE: To explore the role of systematic vaccination management model in mass vaccination of COVID-19 vaccine. METHODS: According to the mass vaccination plan formulated by the Day Clinic of the Fifth Medical Center of Chinese PLA General Hospital, the vaccination work was fully deployed before vaccination;and the temporary specification of mass vaccination sites were set up according to the requirements of the temporary vaccination site for the new coronavirus vaccine in Beijing;the vaccine management systems was strictly implemented, the doctor group, nursing group and guarantee group performed the responsibilities of their own to ensure smooth and orderly vaccination work. RESULTS: The medical center has participated in more than 30 mass vaccinations of COVID-19, no vaccination error-related reactions and psychogenic reactions occurred at the vaccination site, and no adverse events that were caused by problems in the process link occurred. CONCLUSION: The detailed work plan for mass vaccination may facilitate the safe and orderly mass vaccination, and the vaccination work is unanimously recognized by the recipients.
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Purpose: The persistent pandemic of coronavirus disease 2019 (COVID-19), the discovery of gastrointestinal transmission routes and the possible susceptibility of cancer patients to COVID-19 have forced us to search for effective pathways against stomach adenocarcinoma (STAD)/COVID-19. Vitamin D3 (VD3) is a steroid hormone with antiviral, anti-inflammatory and immunomodulatory properties. This study aimed to evaluate the possible functional role and potential mechanisms of action of VD3 as an anti-COVID-19 and anti- STAD. Methods: Clinicopathological analysis, enrichment analysis and protein interaction analysis using bioinformatics and network pharmacology methods. Validate the binding activity of VD3 to core pharmacological targets and viral crystal structures using molecular docking. Results: We revealed the clinical characteristics of STAD/COVID-19 patients. We also demonstrated that VD3 may be anti- STAD/COVID-19 through antiviral, anti-inflammatory, and immunomodulatory pathways. Molecular docking results showed that VD3 binds well to the relevant targets of COVID-19, including the spike RBD/ACE2 complex and main protease (Mpro, also known as 3CLpro). We also identified five core pharmacological targets of VD3 in anti-STAD/COVID-19 and validated the binding activity of VD3 to PAI1 by molecular docking. Conclusion: This study reveals for the first time that VD3 may act on disease target gene SERPINE1 through inflammatory and viral related signaling pathways and biological functions for the therapy of STAD/COVID-19. This may provide a new idea for the use of VD3 in the treatment of STAD/COVID-19.
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OBJECTIVE: Suspected patients with new coronavirus pneumonia (NCP) may suffer from unique mental health problems. However, the shortage of medical personnel and the infectiousness of the disease have challenged traditional psychological interventions. This study investigated the effects of a new WeChat-based psychological intervention on the mental health of suspected NCP patients. METHODS: This study included 48 participants (control group = 24 vs. intervention group = 24). The control group received conventional NCP nursing, and the intervention group received conventional NCP nursing and the WeChat psychological interventions. Participants completed the Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), and Acute Stress Disorder Scale (ASDS) on the day of, and the 14th day after, admission. RESULTS: There were no significant differences between the two groups (p > .05) regarding demographic characteristics, education, work status, anxiety, depression, or acute stress disorder on the day of admission (p > .05). On the 14th day after admission, the intervention group showed an improvement in anxiety (p < .05) and a significant improvement in depression and acute stress disorder compared with the control group (p < .01). CONCLUSION: The WeChat-based psychological interventions can have a positive effect on the mental health problems of suspected NCP patients.
Subject(s)
Mental Health , Pneumonia , Anxiety/therapy , Humans , Pilot Projects , Psychosocial InterventionABSTRACT
Since the outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, a series of confirmed cases of COVID-19 were found on the Qinghai-Tibet plateau. We aimed to describe the epidemiological, clinical characteristics, and outcomes of all confirmed cases in Qinghai, a province at high altitude. The region had no sustained local transmission. Of all 18 patients with confirmed SARS-CoV-2 infection, 15 patients comprising four transmission clusters were identified. Three patients were infected by direct contact without travel history to Wuhan. Of 18 patients, 10 patients showed bilateral pneumonia and two patients showed no abnormalities. Three patients with comorbidities such as hypertension, liver diseases, or diabetes developed severe illness. High C-reactive protein levels and elevations of both alanine aminotransferase and aspartate aminotransferase were observed in three severely ill patients on admission. All 18 patients were eventually discharged, including the three severe patients who recovered after treatment with noninvasive mechanical ventilation, convalescent plasma, and other therapies. Our findings confirmed human-to-human transmission of SARS-CoV-2 in clusters. Patients with comorbidities are more likely to develop severe illness.
ABSTRACT
Since the outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, a series of confirmed cases of COVID-19 were found on the Qinghai-Tibet plateau. We aimed to describe the epidemiological, clinical characteristics, and outcomes of all confirmed cases in Qinghai, a province at high altitude. The region had no sustained local transmission. Of all 18 patients with confirmed SARS-CoV-2 infection, 15 patients comprising 4 transmission clusters were identified. Three patients were infected by direct contact without travel history to Wuhan. Of 18 patients, 10 patients showed bilateral pneumonia and 2 patients showed no abnormalities. Three patients with comorbidities such as hypertension, liver diseases or diabetes developed severe illness. High C-reactive protein levels and elevations of both ALT and AST were observed in 3 severely ill patients on admission. All 18 patients were eventually discharged, including the 3 severe patients who recovered after treatment with non-invasive mechanical ventilation, convalescent plasma and other therapies. Our findings confirmed human-to-human transmission of SARS-CoV-2 in clusters. Patients with comorbidities are more likely to develop severe illness. This article is protected by copyright. All rights reserved.